WebSep 9, 2024 · For general information, Learn About Clinical Studies. Criteria Inclusion Criteria: Males aged 18 years or older Diagnosis of Haemophilia A defined as ≤2% FVIII activity Greater than 150 exposure days to treatment with FVIII products Use of reliable barrier contraception if applicable Normal levels of von Willebrand factor (VWF) antigen WebNov 5, 2024 · Sangamo responds to a clinical hold. Unrelated to the pause of the hemophilia A gene therapy program, Pfizer and the FDA decided not to perform an interim analysis for two hemophilia gene therapy trials, planning instead to wait for complete analyses on 50 or more participants in the hemophilia A trial and 40 in the hemophilia …
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WebApr 1, 2024 · Three patients had (very low to medium titer) ADA+ tests in each trial, with no observed clinical effect. These results support further development of concizumab as a … WebJun 5, 2024 · This is a first-in-human, non-randomized, open label, single treatment, Phase 1 study in approximately 7 patients with severe hemophilia A. The study will evaluate gene therapy by transplantation of autologous CD34+ hematopoietic stem cells transduced ex vivo with the CD68-ET3 lentiviral vector. Detailed Description: erin house prints
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WebMar 29, 2024 · Researchers are looking for a better way to treat hemophilia A. Hemophilia A is a genetic disorder where the body does not create enough of a protein called clotting factor 8 (FVIII) present in the blood. People with hemophilia A may bleed for a… at UC Davis Dose Confirmation Trial of AAV5-hFIXco-Padua in progress, not accepting new … WebSep 22, 2024 · Any disorder, except for conditions associated with haemophilia A, which in the investigator's opinion might jeopardise participant's safety or compliance with the protocol. Known or suspected hypersensitivity to trial product(s), any constituents of the product or to related products. Receipt of gene therapy at any given time point. WebClinical Trials Below is a list of active clinical trials worldwide which involve patients with inherited bleeding disorders. The link from each study title will take you to … find volume of cube formula