Chemerin connects fat to arterial contraction
WebLNNA indicates N-ω-nitro-L-arginine. - "Chemerin Connects Fat to Arterial Contraction" Figure 3. Amplification and ChemR23dependence of Chemerin-9 contraction. A, Left: Sample tracing of the ability of chemerin-9 to cause concentration-, ChemR23-dependent contraction in the aorta with endothelium removed (−E). Right: Quantification of the ... WebMar 20, 2024 · Another PVAT-derived adipokine of interest is chemerin, which can cause contraction in arteries when applied without PVAT. 54 Chemerin is produced in higher quantities in animals fed a high-fat diet and is linked to adipogenesis through the ... Chemerin connects fat to arterial contraction. Arterioscler Thromb Vasc Biol. 2013; …
Chemerin connects fat to arterial contraction
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WebSep 8, 2024 · Some studies also show chemerin can promote arterial contraction by primary chemerin receptor ChemR23 on SMCs. ... Penfold ME, Rourke JL, Sinal CJ, Seitz B, et al. Chemerin connects fat to arterial contraction. Arterioscler Thromb Vasc Biol. (2013) 33:1320–8. doi: 10.1161/ATVBAHA.113.301476. PubMed Abstract CrossRef … WebObjective— Obesity and hypertension are comorbid in epidemic proportion, yet their biological connection is largely a mystery. The peptide chemerin is a candidate for connecting fat deposits around the blood vessel (perivascular adipose tissue) to arterial contraction. We presently tested the hypothesis that chemerin is expressed in …
WebHowever, chemerin and CMKLR1 protein expression was higher in aortic arteries and perivascular adipose tissues of the OIH group ( P <0.05). The arterial tension induced by chemerin 9 (1 μM) and the expression of Rock2 and P-MYPT1 were higher in the OIH group ( P <0.05). Conclusion: OIH positively correlated with chemerin in tissues but not … WebJul 22, 2024 · Background: We previously reported that the adipokine chemerin, when added exogenously to the isolated rat mesenteric artery, amplified electrical field-stimulated (EFS) contraction. The Chemerin1 antagonist CCX832 alone inhibited EFS-induced contraction in tissues with but not without perivascular adipose tissue (PVAT). These …
WebApr 4, 2013 · The peptide chemerin is a candidate for connecting fat deposits around the blood vessel (perivascular adipose tissue, PVAT) to arterial contraction. We presently … WebAug 1, 2015 · Control of peripheral resistance through contraction and relaxation of constituent vascular smooth muscle is a critical function of muscular arteries and arterioles in vivo. ... Chemerin connects fat to arterial contraction. Arterioscler Thromb Vasc Biol. 2013; 33:1320–1328. doi: 10.1161/ATVBAHA.113.301476. Link Google Scholar; 19.
WebApr 4, 2013 · Chemerin, released from fat (perivascular adipose tissue [PVAT], visceral fat) or tissue (liver), stimulates the ChemR23 receptor …
WebJul 31, 2024 · Chemerin is a multifunctional adipokine with established roles in inflammation, adipogenesis and glucose homeostasis. Increasing evidence suggest an … lagu rukun islam anakWebSep 2, 2024 · The adipokine chemerin causes arterial contraction and is implicated in blood pressure regulation, especially in obese subjects with elevated levels of circulating … jeff gmuer plumbingWebMar 15, 2024 · Chemerin connects fat to arterial contraction. Arterioscler Thromb Vasc Biol. 2013; 33:1320–1328. [Europe PMC free article] [Google Scholar] 8. Kunimoto H, Kazama K, Takai M, Oda M, Okada M, Yamawaki H. Chemerin promotes the proliferation and migration of vascular smooth muscle and increases mouse blood pressure. Am J ... jeff gluckWebOct 31, 2024 · The circulating and aortic levels of chemerin increased in the progression of aortic atherosclerosis in ApoE −/− mice. (a) The aortic morphology staining by HE, oil red O, and immunofluorescence assay for chemerin at different stages (0, 4, 8, 12, and 16 W) in ApoE −/− mice fed with high-fat diet. (b), (c), and (d) The ratios of aortic neointima/media … jeff glanzmann subaruWebJun 1, 2013 · Chemerin Connects Fat to Arterial Contraction. Objective—Obesity and hypertension are comorbid in epidemic proportion, yet their biological connection is … jeff gluck nascarWebSep 1, 2015 · Chemerin connects fat to arterial contraction. Arterioscler. Thromb. Vasc. Biol. (2013) J.L. Rourke et al. ... In mice fed a high fat diet hepatic chemerin mRNA but not protein is increased. Chemerin protein is comparably expressed in the liver of control animals and ob/ob mice. Rodents fed a Paigen diet or methionine-choline deficient diet ... jeff gluck surveyWebApr 4, 2013 · The peptide chemerin is a candidate for connecting fat deposits around the blood vessel (perivascular adipose tissue) to arterial contraction. We presently tested … jeff glassman